T-cell leukemia 1 expression in nodal Epstein-Barr virus-negative diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma.

doi:10.1016/j.humpath.2010.01.015

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Article

T-cell leukemia 1 expression in nodal Epstein-Barr virus-negative diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma.

Human pathology - 1 Sept 2010

Gualco Gabriela, Weiss Lawrence M, Barber Glen N, Bacchi Carlos E

Abstract excerpt

The physiologic expression of the product of the proto-oncogene TCL1 (T-cell leukemia 1) is primarily restricted to early embryonic cells. In nonneoplastic B cells, the expression of TCL1 is determined by the differentiation step with silencing at the germinal center stage. TCL1 protein is overexpressed in a wide variety of human diseases. It has been shown that TCL1 is a powerful B-cell oncogene, which has been...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Child
Epstein-Barr Virus Infections
Female
Genes, myc
Herpesvirus 4, Human
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lymph Nodes

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoma, B-Cell

Lymphoma, Large B-Cell, Diffuse

Male

Mediastinal Neoplasms

Source

Open in PubMed

Identifiers

PMID: 20382409
DOI: 10.1016/j.humpath.2010.01.015

Genes

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