Article
Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.
Human reproduction (Oxford, England) - 1 Jun 2010
Aston Kenneth I, Krausz Csilla, Laface Ilaria, Ruiz-Castané E, Carrell Douglas T
Abstract excerpt
BACKGROUND: In spite of tremendous efforts by a number of groups, the search for single nucleotide polymorphisms (SNPs) strongly associated with male factor infertility by means of gene re-sequencing studies has yielded few likely candidates. A recent pilot, genome-wide SNP association study (GWAS) identified a list of SNPs associated with oligozoospermia and azoospermia. This is an expanded follow-up study of...
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