Article
Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines.
The Journal of experimental medicine - 12 Apr 2010
Moody M Anthony, Liao Hua-Xin, Alam S Munir, Scearce Richard M, Plonk M Kelly, Kozink Daniel M, Drinker Mark S, Zhang Ruijun, Xia Shi-Mao, Sutherland Laura L, Tomaras Georgia D, Giles Ian P, Kappes John C, Ochsenbauer-Jambor Christina, Edmonds Tara G, Soares Melina, Barbero Gustavo, Forthal Donald N, Landucci Gary, Chang Connie, King Steven W, Kavlie Anita, Denny Thomas N, Hwang Kwan-Ki, Chen Pojen P, Thorpe Philip E, Montefiori David C, Haynes Barton F
Abstract excerpt
Traditional antibody-mediated neutralization of HIV-1 infection is thought to result from the binding of antibodies to virions, thus preventing virus entry. However, antibodies that broadly neutralize HIV-1 are rare and are not induced by current vaccines. We report that four human anti-phospholipid monoclonal antibodies (mAbs) (PGN632, P1, IS4, and CL1) inhibit HIV-1 CCR5-tropic (R5) primary isolate infection of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.