Article
What have we learned form monogenic forms of severe insulin resistance associated with PCOS/HAIRAN?
Annales d'endocrinologie - 1 May 2010
Vigouroux C
Abstract excerpt
Whatever the origin of severe insulin resistance (primary insulin receptors defects or lipodystrophies), in vivo hyperinsulinemia has been clearly shown to promote ovarian growth and androgen synthesis independently of gonadotropins. In lipodystrophic syndromes, the endocrine deficiency of adipose tissue has been shown to play important pathophysiological roles in metabolic alterations. In particular leptin is...
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