Article
Identification of a splice-site mutation in the human growth hormone-variant gene.
American journal of human genetics - 1 Jun 1991
MacLeod J N, Liebhaber S A, MacGillivray M H, Cooke N E
Abstract excerpt
The human growth-hormone-variant (hGH-V) gene normally expresses two alternatively spliced forms of mRNA--hGH-V and hGH-V2--in the placenta. hGH-V2 mRNA differs from hGH-V rDNA by the retention of intron 4 and represents approximately 15% of transcripts at term. In a survey of hGH-V gene expression in 20 placentas of gestational age 8-40 wk, we detected a single placenta that contained, in addition to the two...
Topics
- Base Sequence
- Electrophoresis, Polyacrylamide Gel
- Female
- Genetic Variation
- Growth Hormone
- Humans
- Molecular Sequence Data
- Mutation
- Placenta
- Polymerase Chain Reaction
- Pregnancy