Article
A difference in the splicing patterns of the closely related normal and variant human growth hormone gene transcripts is determined by a minimal sequence divergence between two potential splice-acceptor sites.
The Journal of biological chemistry - 15 Nov 1990
Estes P A, Cooke N E, Liebhaber S A
Abstract excerpt
The human growth hormone (hGH-N) and the closely related human growth hormone-variant (hGH-V) genes differ in their patterns of splice-site selection. In 9% of hGH-N transcripts exon 2 is spliced to an alternative acceptor site located 45 bases within exon 3. mRNA spliced in this manner encodes a 20-kDa hGH-N isoform instead of the normal 22-kDa hGH-N. The hGH-V transcript fails to utilize this alternative...
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