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Fine-mapping and mutation analysis of TRPM1: a candidate gene for leopard complex (LP) spotting and congenital stationary night blindness in horses.

Briefings in functional genomics - 1 May 2010

Bellone Rebecca R, Forsyth George, Leeb Tosso, Archer Sheila, Sigurdsson Snaevar, Imsland Freyja, Mauceli Evan, Engensteiner Martina, Bailey Ernest, Sandmeyer Lynne, Grahn Bruce, Lindblad-Toh Kerstin, Wade Claire M

Abstract excerpt

Leopard Complex spotting occurs in several breeds of horses and is caused by an incompletely dominant allele (LP). Homozygosity for LP is also associated with congenital stationary night blindness (CSNB) in Appaloosa horses. Previously, LP was mapped to a 6 cm region on ECA1 containing the candidate gene TRPM1 (Transient Receptor Potential Cation Channel, Subfamily M, Member 1) and decreased expression of this...

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Identifiers

PMID: 20353955
DOI: 10.1093/bfgp/elq002

Genes

TRPM1

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Fine-mapping and mutation analysis of TRPM1: a candidate gene for leopard complex (LP) spotting and congenital stationary night blindness in horses.PMID 20353955Read ↗

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