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Article

Cytokine polymorphism in noninfectious uveitis.

Investigative ophthalmology & visual science - 1 Aug 2010

Atan Denize, Fraser-Bell Samantha, Plskova Jarka, Kuffova Lucia, Hogan Aideen, Tufail Adnan, Kilmartin Dara J, Forrester John V, Bidwell Jeff, Dick Andrew D, Churchill Amanda J

Abstract excerpt

PURPOSE: Noninfectious uveitis is a sight-threatening immune-mediated intraocular inflammatory disorder. The inheritance of uveitis in multiplex families and its association with known monogenic and polygenic immunologic disorders suggests that common genetic variants underlie susceptibility to uveitis as well as to other immunologic disorders. TNFA and IL10 are strong candidate genes, given the influence of...

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PMID: 20335604
DOI: 10.1167/iovs.09-4583

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LTA

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