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Evolutionarily Conserved Function of a Viral MicroRNA

7 Aug 2008

Abstract excerpt

MicroRNAs (miRNAs) are potent RNA regulators of gene expression. Some viruses encode miRNAs, most of unknown function. The majority of viral miRNAs are not conserved, and whether any have conserved functions remains unclear. Here, we report that two human polyomaviruses associated with serious disease in immunocompromised individuals, JC virus and BK virus, encode miRNAs with the same function as that of the...

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PMID: 18684810
DOI: 10.1128/jvi.01144-08

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