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Article

Nucleophosmin Phosphorylation by v-Cyclin-CDK6 Controls KSHV Latency

18 Mar 2010

Abstract excerpt

Nucleophosmin (NPM) is a multifunctional nuclear phosphoprotein and a histone chaperone implicated in chromatin organization and transcription control. Oncogenic Kaposi's sarcoma herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD). In the infected host cell KSHV displays two modes of infection, the latency and productive viral...

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PMID: 20333249
DOI: 10.1371/journal.ppat.1000818

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