Article
The mammalian K(IR)2.x inward rectifier ion channel family: expression pattern and pathophysiology.
Acta physiologica (Oxford, England) - 1 Jul 2010
de Boer T P, Houtman M J C, Compier M, van der Heyden M A G
Abstract excerpt
Inward rectifier currents based on K(IR)2.x subunits are regarded as essential components for establishing a stable and negative resting membrane potential in many excitable cell types. Pharmacological inhibition, null mutation in mice and dominant positive and negative mutations in patients reveal some of the important functions of these channels in their native tissues. Here we review the complex mammalian...
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