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Article

Function of phenylalanine 259 and threonine 314 within the substrate binding pocket of the juvenile hormone esterase of Manduca sexta.

Biochemistry - 4 May 2010

Kamita Shizuo G, Wogulis Mark D, Law Christopher S, Morisseau Christophe, Tanaka Hiromasa, Huang Huazhang, Wilson David K, Hammock Bruce D

Abstract excerpt

Juvenile hormone (JH) is a key insect developmental hormone that is found at low nanomolar levels in larval insects. The methyl ester of JH is hydrolyzed in many insects by an esterase that shows high specificity for JH. We have previously determined a crystal structure of the JH esterase (JHE) of the tobacco hornworm Manduca sexta (MsJHE) [Wogulis, M., Wheelock, C. E., Kamita, S. G., Hinton, A. C., Whetstone, P....

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Identifiers

PMID: 20307057
DOI: 10.1021/bi901641x
PMCID: PMC3570046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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