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Article

Characterization of triclosan-resistant mutants reveals multiple antimicrobial resistance mechanisms in Rhodospirillum rubrum S1H.

Applied and environmental microbiology - 1 May 2010

Pycke Benny F G, Crabbé Aurélie, Verstraete Willy, Leys Natalie

Abstract excerpt

Antimicrobial resistance mechanisms were identified in 11 spontaneous high- and low-level triclosan resistance (Tcs(r)) mutants of Rhodospirillum rubrum S1H by genotyping complemented with transcriptional analyses, antibiotic resistance screening, and membrane permeability analyses. High-end Tcs(r) (MIC = 8 mg/liter) was the result of a FabI1(G98V) mutation. This point mutation led to an even higher level of...

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PMID: 20305019
DOI: 10.1128/AEM.02757-09
PMCID: PMC2869150

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