Article
Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese.
Clinica chimica acta; international journal of clinical chemistry - 4 Jul 2010
Wu Yih-Ru, Chen Chiung-Mei, Chen Yi-Chun, Chao Chih-Ying, Ro Long Sun, Fung Hon-Chung, Hsiao Ya-Chin, Hu Fen-Ju, Lee-Chen Guey-Jen
Abstract excerpt
BACKGROUND: Impaired ubiquitin-proteasome system function may contribute to the pathogenesis of Parkinson's disease (PD). METHODS: We conducted a case-control study in a cohort of 517 PD cases and 518 ethnically matched controls to investigate the association of ubiquitin specific proteases USP24 rs487230 C>T, USP40 rs1048603 C>T, and ubiquitin thiolesterase UCHL1 rs5030732 A>C polymorphisms with the risk of PD....
Read the complete abstract on PubMed