Article
The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis.
Arthritis research & therapy - 1 Jan 2010
Willcocks Lisa C, Lyons Paul A, Rees Andrew J, Smith Kenneth G C
Abstract excerpt
The aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis has not been well defined. Here we review two factors which may play a role in the pathogenesis of the disease: genetics and infection. In particular, we discuss the role of autoantibodies to LAMP-2, which may arise following infection with Gram-negative bacteria, and may contribute to the development of ANCA-associated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.