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Animal Models of Lymphangioleiomyomatosis (LAM) and Tuberous Sclerosis Complex (TSC)

1 Mar 2010

Abstract excerpt

Animal models of lymphangioleiomyomatosis (LAM) and tuberous sclerosis complex (TSC) are highly desired to enable detailed investigation of the pathogenesis of these diseases. Multiple rats and mice have been generated in which a mutation similar to that occurring in TSC patients is present in an allele of Tsc1 or Tsc2. Unfortunately, these mice do not develop pathologic lesions that match those seen in LAM or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20235887
DOI: 10.1089/lrb.2009.0013

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