Article
DNA copy numbers profiles in affinity-purified ovarian clear cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2010
Kuo Kuan-Ting, Mao Tsui-Lien, Chen Xu, Feng Yuanjian, Nakayama Kentaro, Wang Yue, Glas Ruth, Ma M Joe, Kurman Robert J, Shih Ie-Ming, Wang Tian-Li
Abstract excerpt
PURPOSE: Advanced ovarian clear cell carcinoma (CCC) is one of the most aggressive ovarian malignancies, in part because it tends to be resistant to platinum-based chemotherapy. At present, little is known about the molecular genetic alterations in CCCs except that there are frequent activating mutations in PIK3CA. The purpose of this study is to comprehensively define the genomic changes in CCC based on DNA copy...
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