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Article

Evaluation of retro-inverso modifications of HTLV-1 protease inhibitors containing a hydroxyethylamine isoster.

Bioorganic & medicinal chemistry - 1 Apr 2010

Tatsumi Tadashi, Awahara Chiyuki, Naka Hiromi, Aimoto Saburo, Konno Hiroyuki, Nosaka Kazuto, Akaji Kenichi

Abstract excerpt

Effects of retro-inverso (RI) modifications of HTLV-1 protease inhibitors containing a hydroxyethylamine isoster backbone were clarified. Construction of the isoster backbone was achieved by a stereoselective aldol reaction. Four diastereomers with different configurations at the isoster hydroxyl site and the scissile site substituent were synthesized. Inhibitory activities of the new inhibitors suggest that...

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Identifiers

PMID: 20226680
DOI: 10.1016/j.bmc.2010.02.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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