Article
Observed association between the HA1 mutation D222G in the 2009 pandemic influenza A(H1N1) virus and severe clinical outcome, Norway 2009-2010.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin - 4 Mar 2010
Kilander A, Rykkvin R, Dudman S G, Hungnes O
Abstract excerpt
Infection with the recently emerged pandemic influenza A(H1N1) virus causes mild disease in the vast majority of cases, but sporadically also very severe disease. A specific mutation in the viral haemagglutinin (D222G) was found with considerable frequency in fatal and severe cases in Norway, but was virtually absent among clinically mild cases. This difference was statistically significant and our data are...
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