Article
Abelson virus transformation prevents TRAIL expression by inhibiting FoxO3a and NF-kappaB.
Molecules and cells - 1 Apr 2010
Wilson Mary K, McWhirter Sarah M, Amin Rupesh H, Huang Dan, Schlissel Mark S
Abstract excerpt
The Abelson Murine Leukemia Virus (A-MuLV) encodes v-Abl, an oncogenic form of the ubiquitous cellular non-receptor tyrosine kinase, c-Abl. A-MuLV specifically transforms murine B cell precursors both in vivo and in vitro. Inhibition of v-Abl by addition of the small molecule inhibitor STI-571 causes these cells to arrest in the G1 phase of the cell cycle prior to undergoing apoptosis. We found that inhibition of...
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