Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Preferential accumulation of 5-aminolevulinic acid-induced protoporphyrin IX in breast cancer: a comprehensive study on six breast cell lines with varying phenotypes.

Journal of biomedical optics - 1 Jan 2000

Millon Stacy R, Ostrander Julie H, Yazdanfar Siavash, Brown J Quincy, Bender Janelle E, Rajeha Anita, Ramanujam Nirmala

Abstract excerpt

We describe the potential of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence as a source of contrast for margin detection in commonly diagnosed breast cancer subtypes. Fluorescence intensity of PpIX in untreated and ALA-treated normal mammary epithelial and breast cancer cell lines of varying estrogen receptor expression were quantitatively imaged with confocal microscopy. Percentage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminolevulinic Acid
Share to Analysis of Variance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Cell Line, Tumor

Share to Contrast Media

Share to Microscopy, Confocal

Share to Protoporphyrins

Share to Spectrometry, Fluorescence

Source

Open in PubMed Open full text

Identifiers

PMID: 20210488
DOI: 10.1117/1.3302811
PMCID: PMC2839804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Preferential accumulation of 5-aminolevulinic acid-induced protoporphyrin IX in breast cancer: a comprehensive study on six breast cell lines with varying phenotypes.PMID 20210488Read ↗

In order for the light to shine so brightly, the darkness must be present—why do cancers fluoresce with 5-aminolaevulinic acid?Semantic proximity Read ↗

Localization of protoporphyrin IX in glioma patients with paired stimulated Raman histology and two-photon excitation fluorescence microscopySemantic proximity Read ↗

The Effects of 5-Aminolevulinic Acid Esters on Protoporphyrin IX Production in Human Adenocarcinoma Cell Lines¶Semantic proximity Read ↗

Fluorescence Polarization of Methylene Blue as a Quantitative Marker of Breast Cancer at the Cellular LevelSemantic proximity Read ↗

ABCG2 expression is related to low 5-ALA photodynamic diagnosis (PDD) efficacy and cancer stem cell phenotype, and suppression of ABCG2 improves the efficacy of PDDSemantic proximity Read ↗

MEK reduces cancer-specific PpIX accumulation through the RSK-ABCB1 and HIF-1α-FECH axesSemantic proximity Read ↗

Comparative Analysis of 5-ALA and Fluorescent Techniques in High-Grade Glioma TreatmentSemantic proximity Read ↗

Diagnostic Utility of Fluorescence and Diffuse Reflectance Imaging in Gastrointestinal Luminal PathologySemantic proximity Read ↗

Autofluorescence Spectroscopy of Normal and Malignant Human Breast Cell Lines¶Semantic proximity Read ↗

Quantitative Characterization of Duodenal Gastrinoma Autofluorescence using Multi-photon MicroscopySemantic proximity Read ↗

Mechanism of cell death by 5‐aminolevulinic acid‐based photodynamic action and its enhancement by ferrochelatase inhibitors in human histiocytic lymphoma cell line U937Semantic proximity Read ↗

Out of the darkness and into the light: bright field in situ hybridisation for delineation of ERBB2 (HER2) status in breast carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.