Article
Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma.
The Journal of experimental medicine - 15 Mar 2010
Helfrich Iris, Scheffrahn Inka, Bartling Sönke, Weis Joachim, von Felbert Verena, Middleton Mark, Kato Masahi, Ergün Süleyman, Augustin Helmut G, Schadendorf Dirk
Abstract excerpt
Angiogenesis is not only dependent on endothelial cell invasion and proliferation, it also requires pericyte coverage of vascular sprouts for stabilization of vascular walls. Clinical efficacy of angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signaling pathway is...
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