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Article

A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts.

Nature - 1 Jan 2000

Anderson R G, Goldstein J L, Brown M S

Abstract excerpt

Low density lipoprotein is taken up by cultured human fibroblasts through an endocytic process that requires the binding of the lipoprotein to specific receptors located in coated pits on the cell surface. The coated pits are discrete segments of the plasms membrane that can undergo rapid invagination to form coated endocytic vesicles. In one form of the human genetic disorder familial hypercholesterolaemia, the...

Topics

Alleles
Autoradiography
Cell Membrane
Cells, Cultured
Endocytosis
Humans
Hypercholesterolemia
Lipoproteins, LDL
Membrane Proteins
Receptors, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 201867
DOI: 10.1038/270695a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-201867-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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