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Article

Lack of adrenomedullin affects growth and differentiation of adult neural stem/progenitor cells.

Cell and tissue research - 1 Apr 2010

Vergaño-Vera Eva, Fernández Ana P, Hurtado-Chong Anahí, Vicario-Abejón Carlos, Martínez Alfredo

Abstract excerpt

Adrenomedullin (AM) is a peptide hormone involved in the modulation of cellular growth, migration, apoptosis, and angiogenesis. These characteristics suggest that AM is involved in the control of neural stem/progenitor cell (NSPC) biology. To explore this hypothesis, we have obtained NSPC from the olfactory bulb of adult wild-type animals and brain conditional knockouts for adm, the gene that produces AM....

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PMID: 20182890
DOI: 10.1007/s00441-010-0934-3

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