Article
Prognostic significance of histological grading, p53 status, YKL-40 expression, and IDH1 mutations in pediatric high-grade gliomas.
Journal of neuro-oncology - 1 Sept 2010
Antonelli Manila, Buttarelli Francesca Romana, Arcella Antonietta, Nobusawa Sumihito, Donofrio Vittoria, Oghaki Hiroko, Giangaspero Felice
Abstract excerpt
The objective of this study was to evaluate, in a series of 43 pediatric high-grade gliomas (21 anaplastic astrocytoma WHO grade III and 22 glioblastoma WHO grade IV), the prognostic value of histological grading and expression of p53 and YKL-40. Moreover, mutational screening for TP53 and IDH1 was performed in 27 of 43 cases. The prognostic stratification for histological grading showed no difference in overall...
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