Article
Whole-genome linkage scan for epilepsy-related photosensitivity: a mega-analysis.
Epilepsy research - 1 May 2010
de Kovel C G F, Pinto D, Tauer U, Lorenz S, Muhle H, Leu C, Neubauer B A, Hempelmann A, Callenbach P M C, Scheffer I E, Berkovic S F, Rudolf G, Striano P, Siren A, Baykan B, Sander T, Lindhout D, Kasteleijn-Nolst Trenité D G, Stephani U, Koeleman B P C
Abstract excerpt
Photoparoxysmal response (PPR) is considered to be a risk factor for idiopathic generalised epilepsy (IGE) and it has a strong genetic basis. Two genome-wide linkage studies have been published before and they identified loci for PPR at 6p21, 7q32, 13q13, 13q31 and 16p13. Here we combine these studies, augmented with additional families, in a mega-analysis of 100 families. Non-parametric linkage analysis...
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