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Article

Association study of TRPC4 as a candidate gene for generalized epilepsy with photosensitivity.

Neuromolecular medicine - 1 Sept 2010

von Spiczak Sarah, Muhle Hiltrud, Helbig Ingo, de Kovel Carolien G F, Hampe Jochen, Gaus Verena, Koeleman Bobby P C, Lindhout Dick, Schreiber Stefan, Sander Thomas, Stephani Ulrich

Abstract excerpt

Photoparoxysmal response (PPR) is characterized by abnormal visual sensitivity of the brain to photic stimulation. Frequently associated with idiopathic generalized epilepsies (IGEs), it might be an endophenotype for cortical excitability. Transient receptor potential cation (TRPC) channels are involved in the generation of epileptiform discharges, and TRPC4 constitutes the main TRPC channel in the central...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 20574736
DOI: 10.1007/s12017-010-8122-x

Genes

TRPC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association study of TRPC4 as a candidate gene for generalized epilepsy with photosensitivity.PMID 20574736Read ↗

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Explorative two-locus linkage analysis suggests a multiplicative interaction between the 7q32 and 16p13 myoclonic seizures-related photosensitivity loci.Semantic proximity Read ↗

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