Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism-based inactivation of bovine adrenal cytochromes P450 C-21 and P450 17 alpha by 17 beta-substituted steroids.

Biochemistry - 16 Apr 1991

Stevens J C, Jaw J Y, Peng C T, Halpert J

Abstract excerpt

A series of progesterone derivatives has been studied as potential inactivators of the bovine adrenocortical cytochromes P450, P450 17 alpha, and P450 C-21. Replacement of the 21-methyl group of progesterone with a difluoromethyl group resulted in a selective inactivator of P450 C-21 in a reconstituted system. The loss of 21-hydroxylase activity caused by this compound exhibits a number of characteristics of...

Topics

Adrenal Glands
Animals
Cattle
Enzyme Activation
Kinetics
Liver
Mutation
NADP
Progesterone
Rabbits
Rats
Steroid 17-alpha-Hydroxylase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Steroid 21-Hydroxylase

Steroid Hydroxylases

Substrate Specificity

Source

Identifiers

PMID: 2015223
DOI: 10.1021/bi00229a009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2015223-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Mechanism-based inactivation of bovine adrenal cytochromes P450 C-21 and P450 17 alpha by 17 beta-substituted steroids.PMID 2015223Read ↗

Modification of serine 360 by a reactive intermediate of 17-alpha-ethynylestradiol results in mechanism-based inactivation of cytochrome P450s 2B1 and 2B6.Semantic proximity Read ↗

Identification of amino acid residues involved in the inactivation of cytochrome P450 2B1 by two acetylenic compounds: the role of three residues in nonsubstrate recognition Sites.Semantic proximity Read ↗

17α-Hydroxylase/17,20-Lyase Deficiency: From Clinical Investigation to Molecular Definition*Semantic proximity Read ↗

Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia.Semantic proximity Read ↗

Steroid 21-hydroxylase deficiency (congenital adrenal hyperplasia).Semantic proximity Read ↗

Mutations in steroid 21-hydroxylase (CYP21).Semantic proximity Read ↗

A rational approach to Re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5.Semantic proximity Read ↗

Naturally occurring mutants of human steroid 21-hydroxylase (P450c21) pinpoint residues important for enzyme activity and stability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.