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Article

Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia.

The Journal of biological chemistry - 30 Jun 2017

Wang Chunxue, Pallan Pradeep S, Zhang Wei, Lei Li, Yoshimoto Francis K, Waterman Michael R, Egli Martin, Guengerich F Peter

Abstract excerpt

Cytochrome P450 (P450, CYP) 21A2 is the major steroid 21-hydroxylase, converting progesterone to 11-deoxycorticosterone and 17α-hydroxyprogesterone (17α-OH-progesterone) to 11-deoxycortisol. More than 100 CYP21A2 variants give rise to congenital adrenal hyperplasia (CAH). We previously reported a structure of WT human P450 21A2 with bound progesterone and now present a structure bound to the other substrate...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 28539365
DOI: 10.1074/jbc.M117.792465
PMCID: PMC5491764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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