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Engineering M13 bacteriophage to display HER2 mimotopes on pVIII for vaccine development

1 Jul 2025

Abstract excerpt

HER2-positive breast cancer is a subtype characterized by overexpression of the human epidermal growth factor receptor 2 (HER2), which is associated with aggressive tumor growth and poor prognosis. Peptide mimics of HER2 epitopes, recognized by tumor growth-inhibitory antibodies like trastuzumab, have the potential to be developed into effective vaccines. Active immunization with these mimotopes could induce...

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PMID: 40596331
DOI: 10.1038/s41598-025-08032-z

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