Folding in vitro and transport in vivo of pre-beta-lactamase are SecB independent.

Article

Folding in vitro and transport in vivo of pre-beta-lactamase are SecB independent.

Molecular microbiology - 1 Jan 1991

Laminet A A, Kumamoto C A, Plückthun A

Abstract excerpt

The rate of folding of the precursor of beta-lactamase is not influenced by the presence of SecB under conditions in which GroEL/ES retards the folding. Wild-type beta-lactamase and several mutants in the signal or the mature protein, affecting either transport or enzyme kinetics and probably fol...

Topics

Bacterial Proteins
Biological Transport
Cross-Linking Reagents
Enzyme Precursors
Escherichia coli
Immunoblotting
Kinetics
Mutation
Protein Conformation
beta-Lactamases

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