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Article

Neural crest cell origin and signals for intrinsic neurogenesis in the mammalian respiratory tract.

American journal of respiratory cell and molecular biology - 1 Mar 2011

Langsdorf Aliete, Radzikinas Kelsi, Kroten Amanda, Jain Sanjay, Ai Xingbin

Abstract excerpt

Our study investigates the innervation of the respiratory tract during mouse embryonic development, with a focus on the identification of cell origin and essential developmental signals for the resident, or intrinsic, neurons. Using lineage tracing, we show that these intrinsic neurons are exclusively derived from neural crest cells, and cluster to form ganglia that reside in the dorsal trachea and medial bronchi...

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Identifiers

PMID: 20139349
DOI: 10.1165/rcmb.2009-0462OC
PMCID: PMC3159091

Genes

GDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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