Article
The mutations in the fibronectin gene described in Japanese patients with systemic sclerosis are not present in Dutch patients.
Arthritis and rheumatism - 1 Apr 1991
Verheijen R, Oberyé E H, van den Hoogen F H, van Venrooij W J
Abstract excerpt
Recently, a mutant fibronectin gene was identified in skin fibroblasts obtained from sclerotic lesions of 7 Japanese patients with systemic sclerosis (SSc). Two point mutations were found adjacent to the cell-attachment tetrapeptide DNA sequence in exon 7 of the fibronectin gene. In the present study, we investigated whether these point mutations are present in the fibronectin gene of Dutch patients with SSc. We...
Topics
- Base Sequence
- Exons
- Fibronectins
- Genes
- Humans
- Japan
- Molecular Sequence Data
- Mutation
- Netherlands
- Polymerase Chain Reaction
- Scleroderma, Systemic