Article
Screening of DNA-variants in the properdin gene (CFP) in age-related macular degeneration (AMD).
Molecular immunology - 1 Mar 2010
Seitsonen Sanna, Onkamo Päivi, Torniainen Suvi, Ihalainen Milla, Immonen Ilkka, Meri Seppo, Järvelä Irma
Abstract excerpt
Several variants in the complement cascade genes (complement factor H [CFH], C2, C3, CFB, and Serping1) have been reported to associate with age-related macular degeneration (AMD). Of these, a member of the complement alternative pathway, CFH, represents the highest risk. As properdin (P) is also an important protein in this pathway, we analysed whether variants in the properdin gene (CFP) at Xp11.4 are...
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