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Article

Allergy Risk Is Mediated by Dendritic Cells with Congenital Epigenetic Changes

29 Jan 2010

Abstract excerpt

One factor predisposing toward allergic responses is a maternal history of allergy. In a mouse model of maternal transmission of asthma risk, offspring of asthmatic, but not normal, mothers show increased allergic susceptibility, recreating epidemiologic observations in humans. Dendritic cells (DCs) capture and process antigens, and can skew immune responses toward a pro-allergic T helper 2 phenotype. Genome-wide...

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PMID: 20118218
DOI: 10.1165/rcmb.2009-0400oc

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