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Article

REVIEW ARTICLE: Maternal Transmission of Asthma Risk

12 Nov 2008

Abstract excerpt

Maternal asthma significantly increases the risk of asthma in offspring, but the mechanisms remain poorly defined. We review animal models used to study the maternal effect, focusing on a murine model developed in our laboratory. Mother mice rendered allergic to ovalbumin produce offspring that are more susceptible to allergic sensitization, seen as airway hyperresponsiveness and allergic airway inflammation...

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PMID: 19007349
DOI: 10.1111/j.1600-0897.2008.00671.x

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