Article
Transient reappearance of serum hepatitis C virus RNA observed by real-time PCR during antiviral therapy with peginterferon and ribavirin in patients with HCV genotype 1b.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Mar 2010
Toyoda Hidenori, Kumada Takashi, Kiriyama Seiki, Tanikawa Makoto, Hisanaga Yasuhiro, Kanamori Akira, Tada Toshifumi, Takagi Makiko, Hiramatsu Takeshi, Hosokawa Takanori, Arakawa Takahiro, Fujimori Masashi
Abstract excerpt
BACKGROUND: The "response-guided therapy" based on response of hepatitis C virus (HCV) during antiviral combination therapy with peginterferon and ribavirin is important for patients with HCV genotype 1. However, the sensitivity of previous assays for serum HCV RNA is limited. OBJECTIVES: We evaluated the changes in serum HCV RNA during the combination therapy using a novel method for measurement based on...
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