Article
Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation.
Molecular cancer therapeutics - 1 Jan 2014
Neel Nicole F, Stratford Jeran K, Shinde Vaishali, Ecsedy Jeffrey A, Martin Timothy D, Der Channing J, Yeh Jen Jen
Abstract excerpt
The high prevalence of KRAS mutations and importance of the RalGEF-Ral pathway downstream of activated K-ras in pancreatic ductal adenocarcinoma (PDAC) emphasize the importance of identifying novel methods by which to therapeutically target these pathways. It was recently demonstrated that phosphorylation of RalA S194 by Aurora A kinase (AAK) is critical for PDAC tumorigenesis. We sought to evaluate the...
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