Article
Examination of the MASH1 gene in patients with Parkinson's disease.
Biochemical and biophysical research communications - 19 Feb 2010
Deng Hao, Yang Huarong, Le Weidong, Deng Xiong, Xu Hongbo, Xiong Wei, Zhu Shaihong, Xie Wenjie, Song Zhi, Jankovic Joseph
Abstract excerpt
Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The mammalian achaete-scute homolog 1 gene (MASH1) controls development of the locus coeruleus. Furthermore, polyglutamine length variation in MASH1 gene appears to confer protective effects against PD, at least in Japanese population. To determine whether genetic variation in the coding...
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