Article
Further evaluation of a mutagen-attenuated Rift Valley fever vaccine in sheep.
Vaccine - 1 Jan 1991
Morrill J C, Carpenter L, Taylor D, Ramsburg H H, Quance J, Peters C J
Abstract excerpt
A previous study demonstrated that a mutagen-attenuated Rift Valley fever virus (RVFV) vaccine, RVF MP-12, was immunogenic and non-abortogenic when ewes, 90-110 days pregnant, were inoculated with 5 x 10(5) plaque-forming units (p.f.u.) of the virus strain. The ewes delivered live, healthy lambs that had no neutralizing antibody to RVFV until after they had ingested colostrum. To assess further the safety and...
Topics
- Animals
- Antibodies, Viral
- Evaluation Studies as Topic
- Female
- Mutation
- Neutralization Tests
- Rift Valley Fever
- Rift Valley fever virus
- Sheep
- Sheep Diseases
- Vaccines, Attenuated