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Perspectives of Next-Generation Live-Attenuated Rift Valley Fever Vaccines for Animal and Human Use

21 Mar 2023

Abstract excerpt

Live-attenuated Rift Valley fever (RVF) vaccines transiently replicate in the vaccinated host, thereby effectively initiating an innate and adaptive immune response. Rift Valley fever virus (RVFV)-specific neutralizing antibodies are considered the main correlate of protection. Vaccination with classical live-attenuated RVF vaccines during gestation in livestock has been associated with fetal malformations,...

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PMID: 36992291
DOI: 10.3390/vaccines11030707

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