Article
Growth hormone and insulin-like growth factor I insensitivity of fibroblasts isolated from a patient with an I{kappa}B{alpha} mutation.
The Journal of clinical endocrinology and metabolism - 1 Mar 2010
Wu Shufang, Walenkamp Marie J, Lankester Arjan, Bidlingmaier Martin, Wit Jan M, De Luca Francesco
Abstract excerpt
CONTEXT: NF-kappaB is a family of transcription factors involved in cell proliferation, differentiation, and apoptosis. OBJECTIVE: We have recently demonstrated that NF-kappaB is expressed in the growth plate and it mediates the growth-promoting effects of IGF-I on chondrogenesis and longitudinal bone growth. Humans with defects of the NF-kappaB pathway exhibit growth failure, which suggests a possible regulatory...
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