Article
Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses.
Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 2010
Maughan Spencer C, Pasternak Maciej, Cairns Narelle, Kiddle Guy, Brach Thorsten, Jarvis Renee, Haas Florian, Nieuwland Jeroen, Lim Benson, Müller Christopher, Salcedo-Sora Enrique, Kruse Cordula, Orsel Mathilde, Hell Rüdiger, Miller Anthony J, Bray Patrick, Foyer Christine H, Murray James A H, Meyer Andreas J, Cobbett Christopher S
Abstract excerpt
In Arabidopsis thaliana, biosynthesis of the essential thiol antioxidant, glutathione (GSH), is plastid-regulated, but many GSH functions, including heavy metal detoxification and plant defense activation, depend on cytosolic GSH. This finding suggests that plastid and cytosol thiol pools are closely integrated and we show that in Arabidopsis this integration requires a family of three plastid thiol transporters...
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