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Article

Composite system mediates two-step DNA uptake into Helicobacter pylori.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 2010

Stingl Kerstin, Müller Stephanie, Scheidgen-Kleyboldt Gerda, Clausen Martin, Maier Berenike

Abstract excerpt

The Gram-negative gastric pathogen Helicobacter pylori depends on natural transformation for genomic plasticity, which leads to host adaptation and spread of resistances. Here, we show that H. pylori takes up covalently labeled fluorescent DNA preferentially at the cell poles and that uptake is dependent on the type IV secretion system ComB. By titration of external pH and detection of accessibility of the...

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Identifiers

PMID: 20080542
DOI: 10.1073/pnas.0909955107
PMCID: PMC2824268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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