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Article

Macrophages: do they impact AIDS progression more than CD4 T cells?

6 Jan 2010

Abstract excerpt

Abstract Data review of the hypothesis that damage in the monocyte/macrophage arm of innate immunity is a key component predicting AIDS progression. Destruction of CD4+ T cells is considered to be the main cause of immunodeficiency manifested by opportunistic infections in HIV-1-infected humans, as well as in SIV-infected macaques. We propose that monocyte/macrophage lineage cells also play an important role in...

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PMID: 20053708
DOI: 10.1189/jlb.0909626

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