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Article

The therapeutic promise of the cancer stem cell concept

4 Jan 2010

Abstract excerpt

Cancer stem cells (CSCs) are a subpopulation of tumor cells that selectively possess tumor initiation and self-renewal capacity and the ability to give rise to bulk populations of nontumorigenic cancer cell progeny through differentiation. As we discuss here, they have been prospectively identified in several human malignancies, and their relative abundance in clinical cancer specimens has been correlated with...

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PMID: 20051635
DOI: 10.1172/jci41004

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