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Article

Highly suppressing wild-type HIV-1 and Y181C mutant HIV-1 strains by 10-chloromethyl-11-demethyl-12-oxo-calanolide A with druggable profile.

Journal of medicinal chemistry - 11 Feb 2010

Xue Hai, Lu Xiaofan, Zheng Purong, Liu Li, Han Chunyan, Hu Jinping, Liu Zijie, Ma Tao, Li Yan, Wang Lin, Chen Zhiwei, Liu Gang

Abstract excerpt

We herein report a new compound: 10-chloromethyl-11-demethyl-12-oxo-calanolide A (20, EC(50) = 7.4 nM, SI = 1417), which demonstrates a druggable profile with 32.7% oral bioavailability in rat, tolerated oral single dose toxicity in mice, and especially the feature of highly efficient suppression...

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Identifiers

PMID: 20050672
DOI: 10.1021/jm901653e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20050672-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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