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Article

Vesicular Stomatitis Virus Genomic RNA PersistsIn Vivoin the Absence of Viral Replication

24 Dec 2009

Abstract excerpt

Our previous studies using intranasal inoculation of mice with vesicular stomatitis virus (VSV) vaccine vectors showed persistence of vector genomic RNA (gRNA) for at least 60 days in lymph nodes in the absence of detectable infectious virus. Here we show high-level concentration of virus and gRNA in lymph nodes after intramuscular inoculation of mice with attenuated or single-cycle VSV vectors as well as...

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PMID: 20032173
DOI: 10.1128/jvi.02052-09

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