Article
A common variant of the FTO gene is associated with not only increased adiposity but also elevated blood pressure in French Canadians.
Circulation. Cardiovascular genetics - 1 Jun 2009
Pausova Zdenka, Syme Catriona, Abrahamowicz Michal, Xiao Yongling, Leonard Gabriel T, Perron Michel, Richer Louis, Veillette Suzanne, Smith George Davey, Seda Ondrej, Tremblay Johanne, Hamet Pavel, Gaudet Daniel, Paus Tomas
Abstract excerpt
BACKGROUND: FTO is the first gene established as contributing to common forms of obesity. The gene is highly expressed in the hypothalamus and is thought to mediate this effect through its influence on energy homeostasis. The hypothalamus, however, also regulates blood pressure (BP). Therefore, we investigated whether the FTO-risk variant is associated not only with increased adiposity but also with elevated BP...
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