Article
Genetic polymorphism at the apolipoprotein E locus affects the outcome of chronic hepatitis B.
Journal of medical virology - 1 Feb 2010
Toniutto Pierluigi, Fattovich Giovanna, Fabris Carlo, Minisini Rosalba, Burlone Michela, Pravadelli Cecilia, Peraro Laura, Falleti Edmondo, Caldera Francesca, Bitetto Davide, Pirisi Mario
Abstract excerpt
Apolipoprotein E (ApoE) and H (ApoH) genotypes are known to affect plasma lipoprotein concentrations. By modulating transport and entry of the hepatitis B virus into hepatocytes, apolipoproteins may influence the course of infection. To verify this hypothesis, 105 patients with chronic HBV infection were examined. Sixty-two of the patients were followed-up for a median time of 21 years. One hundred two controls...
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